AustralieFrV1, Main, Exploration, bibRecord, 004C46

Structure and function of the ascending aorta in palliated transposition of the great arteries

Identifieur interne : 004C46 ( Main/Exploration ); précédent : 004C45; suivant : 004C47

Structure and function of the ascending aorta in palliated transposition of the great arteries

Auteurs : Magalie Ladouceur [France] ; Nadjia Kachenoura [France] ; Muriel Lefort [France] ; Alban Redheuil [France] ; Damien Bonnet [France] ; David S. Celermajer [Australie] ; Laurence Iserin [France] ; Elie Mousseaux [France]

Source :

International journal of cardiology [ 0167-5273 ] ; 2013.

RBID : Pascal:13-0185236

Descripteurs français

Pascal (Inist)
- Transposition des gros vaisseaux, Pathologie de l'appareil circulatoire, Structure, Aorte ascendante, Imagerie RMN, Cardiologie.

English descriptors

KwdEn :
- Ascending aorta, Cardiology, Cardiovascular disease, Nuclear magnetic resonance imaging, Structure, Transposition of the great vessels.

Abstract

Background: In transposition of the great arteries (TGA), the right ventricle (RV) is subaortic and abnormal aortic structure or function could adversely affect the capacity of the RV to supply the systemic circulation. Our aim was to assess aortic dimensions and distensibility and RV function in patients with palliated TGA using cardiovascular magnetic resonance imaging (CMR). Methods: We studied 29 patients (22 males; age 29 ± 4 years) with simple TGA, who underwent an atrial switch procedure, and 29 age and sex matched controls. All subjects had cine and phase contrast CMR to evaluate aortic function and global RV function. Results: TGA patients had significant dilatation of the aortic annulus (21.0±3.6 mm vs. 17.6±4.1 mm, p=0.002) and the sinus of Valsalva (30.0±4 mm vs. 26.8±4.2 mm, p=0.005,) compared to controls. These findings were associated with reduced distensibility of the ascending aorta in patients with TGA (3.5±1.6 vs. 5.3±2.4 mmHg^-1. 10^-3, p=0.0009). We could not show a significant correlation between aortic stiffness indices and RV size, function, mass or presence of fibrosis. Conclusion: The aortic root dilates and the ascending aorta stiffens in TGA, during young adult life. Although these proximal aortic changes did not show adverse effects on the RV in our young TGA sample, they might have important long-term physiopathological consequences in these patients.

Affiliations:

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Le document en format XML

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<author><name sortKey="Mousseaux, Elie" sort="Mousseaux, Elie" uniqKey="Mousseaux E" first="Elie" last="Mousseaux">Elie Mousseaux</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>INSERM, UMRS 678, Universite Pierre et Marie Curie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Pierre-et-Marie-Curie</orgName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Radiology, APHP-Hôpital Europeen Georges Pompidou</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Université Paris Descartes</s1>
<s2>Paris 75006</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>75006</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Paris-Descartes</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">International journal of cardiology</title>
<title level="j" type="abbreviated">Int. j. cardiol.</title>
<idno type="ISSN">0167-5273</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">International journal of cardiology</title>
<title level="j" type="abbreviated">Int. j. cardiol.</title>
<idno type="ISSN">0167-5273</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Ascending aorta</term>
<term>Cardiology</term>
<term>Cardiovascular disease</term>
<term>Nuclear magnetic resonance imaging</term>
<term>Structure</term>
<term>Transposition of the great vessels</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Transposition des gros vaisseaux</term>
<term>Pathologie de l'appareil circulatoire</term>
<term>Structure</term>
<term>Aorte ascendante</term>
<term>Imagerie RMN</term>
<term>Cardiologie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: In transposition of the great arteries (TGA), the right ventricle (RV) is subaortic and abnormal aortic structure or function could adversely affect the capacity of the RV to supply the systemic circulation. Our aim was to assess aortic dimensions and distensibility and RV function in patients with palliated TGA using cardiovascular magnetic resonance imaging (CMR). Methods: We studied 29 patients (22 males; age 29 ± 4 years) with simple TGA, who underwent an atrial switch procedure, and 29 age and sex matched controls. All subjects had cine and phase contrast CMR to evaluate aortic function and global RV function. Results: TGA patients had significant dilatation of the aortic annulus (21.0±3.6 mm vs. 17.6±4.1 mm, p=0.002) and the sinus of Valsalva (30.0±4 mm vs. 26.8±4.2 mm, p=0.005,) compared to controls. These findings were associated with reduced distensibility of the ascending aorta in patients with TGA (3.5±1.6 vs. 5.3±2.4 mmHg<sup>-1</sup>
. 10<sup>-3</sup>
, p=0.0009). We could not show a significant correlation between aortic stiffness indices and RV size, function, mass or presence of fibrosis. Conclusion: The aortic root dilates and the ascending aorta stiffens in TGA, during young adult life. Although these proximal aortic changes did not show adverse effects on the RV in our young TGA sample, they might have important long-term physiopathological consequences in these patients.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
<region><li>Nouvelle-Galles du Sud</li>
<li>Île-de-France</li>
</region>
<settlement><li>Paris</li>
<li>Sydney</li>
</settlement>
<orgName><li>Université Paris-Descartes</li>
<li>Université Pierre-et-Marie-Curie</li>
<li>Université de Sydney</li>
</orgName>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Ladouceur, Magalie" sort="Ladouceur, Magalie" uniqKey="Ladouceur M" first="Magalie" last="Ladouceur">Magalie Ladouceur</name>
</region>
<name sortKey="Bonnet, Damien" sort="Bonnet, Damien" uniqKey="Bonnet D" first="Damien" last="Bonnet">Damien Bonnet</name>
<name sortKey="Iserin, Laurence" sort="Iserin, Laurence" uniqKey="Iserin L" first="Laurence" last="Iserin">Laurence Iserin</name>
<name sortKey="Iserin, Laurence" sort="Iserin, Laurence" uniqKey="Iserin L" first="Laurence" last="Iserin">Laurence Iserin</name>
<name sortKey="Kachenoura, Nadjia" sort="Kachenoura, Nadjia" uniqKey="Kachenoura N" first="Nadjia" last="Kachenoura">Nadjia Kachenoura</name>
<name sortKey="Ladouceur, Magalie" sort="Ladouceur, Magalie" uniqKey="Ladouceur M" first="Magalie" last="Ladouceur">Magalie Ladouceur</name>
<name sortKey="Ladouceur, Magalie" sort="Ladouceur, Magalie" uniqKey="Ladouceur M" first="Magalie" last="Ladouceur">Magalie Ladouceur</name>
<name sortKey="Lefort, Muriel" sort="Lefort, Muriel" uniqKey="Lefort M" first="Muriel" last="Lefort">Muriel Lefort</name>
<name sortKey="Mousseaux, Elie" sort="Mousseaux, Elie" uniqKey="Mousseaux E" first="Elie" last="Mousseaux">Elie Mousseaux</name>
<name sortKey="Mousseaux, Elie" sort="Mousseaux, Elie" uniqKey="Mousseaux E" first="Elie" last="Mousseaux">Elie Mousseaux</name>
<name sortKey="Mousseaux, Elie" sort="Mousseaux, Elie" uniqKey="Mousseaux E" first="Elie" last="Mousseaux">Elie Mousseaux</name>
<name sortKey="Redheuil, Alban" sort="Redheuil, Alban" uniqKey="Redheuil A" first="Alban" last="Redheuil">Alban Redheuil</name>
<name sortKey="Redheuil, Alban" sort="Redheuil, Alban" uniqKey="Redheuil A" first="Alban" last="Redheuil">Alban Redheuil</name>
<name sortKey="Redheuil, Alban" sort="Redheuil, Alban" uniqKey="Redheuil A" first="Alban" last="Redheuil">Alban Redheuil</name>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Celermajer, David S" sort="Celermajer, David S" uniqKey="Celermajer D" first="David S." last="Celermajer">David S. Celermajer</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Structure and function of the ascending aorta in palliated transposition of the great arteries

Structure and function of the ascending aorta in palliated transposition of the great arteries

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